Biotin and derivatives
Sigma Aldrich Fine Chemicals Biosciences Biotinamidohexanoic acid N-hydroxysuccinimide ester >=98% (TLC), powder | 72040-63-2 | MFCD00065502 | 10MG
Biotinamidohexanoic acid N-hydroxysuccinimide ester >=98% (TLC), powder | Purity: >=98% (TLC) | Mol Wt: 454.54 | 72040-63-2 | MFCD00065502 | 10MG
Medchemexpress LLC DBCO-N-bis(PEG4-NHS ester) | 2639395-38-1 | 96.2% | 995.03 g/mol | C49H62N4O18 | 10 MG
DBCO-N-bis(PEG4-NHS ester) is a PEG-based bifunctional linker that contains a dibenzocyclooctyne (DBCO) group and two PEG4-NHS ester reactive ends. It is designed for click chemistry applications, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) for protein modification, labeling, and use as a linker in conjugate syntheses.
- Contains two PEG4-NHS ester groups and one DBCO group.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Suitable for protein modification and labeling applications.
- Molecular weight 995.03 g/mol; formula C49H62N4O18.
- Purity approximately 96.2%.
- Available in small quantities (for example, 10 mg) for laboratory use.
- Storage: pure form -20 °C (long-term); in solvent -80 °C (recommended for extended storage).
Medchemexpress LLC Biotin-ATRA-conjugate | 2226143-93-5 | 98.4% | C36H55N3O4S | 10MG
ATRA-biotin (biotin-ATRA-conjugate) is a biotin-labeled derivative of all-trans retinoic acid used as a tracer and affinity reagent to track ATRA distribution and interactions in biological samples. It supports biotin-streptavidin workflows and is supplied at high purity for research use only.
- Biotin tag enables streptavidin-based detection.
- Suitable for localization studies in cells and tissues.
- Compatible with pull-down and affinity capture assays.
- High purity for reproducible experimental results.
- Available in multiple laboratory-friendly pack sizes.
Medchemexpress LLC Biotin-PEG11-amine | 1418022-42-0 | 99.85% | C34H66N4O13S | 50 MG
Biotin-PEG11-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Research Products International Corp D Biotin 5 G
CAS Number: 58-85-5
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.3
Medchemexpress LLC m-PEG-NHS ester | 92451-01-9 | MFCD06412227 | 98.0% | 2,000 Da | C9H13NO6 | 500 MG
m-PEG-NHS ester is a methoxy-terminated polyethylene glycol reagent functionalized with an N-hydroxysuccinimide (NHS) ester for selective conjugation to primary amines. With an average molecular weight of approximately 2,000 Da, it is used to introduce PEG chains that improve solubility, stability, and circulation time of proteins, peptides, and small molecules. Supplied as a 500 mg solid.
- Methoxy-terminated PEG with NHS ester reactive group.
- Average molecular weight ~2,000 Da for spacer and solubility enhancement.
- High purity suitable for bioconjugation (reported 98.0%).
- Reacts selectively with primary amines to form stable amide linkages.
- Commonly used for PEGylation, linker construction, and bioconjugation.
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 250 MG
Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 250 MG
Medchemexpress LLC 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 250 MG
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker designed for use in the synthesis of PROTACs. These compounds exploit the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins, offering a novel approach for targeted therapy.
- Utilized in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Alkyl/ether-based linker
Medchemexpress LLC Tri-GalNAc biotin | 00-00-0 | 99.8% | C83H146N14O34S | 10MG
tri-GalNAc biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand used for lysosome-targeting chimera (LYTAC) research. It promotes ASGPR-mediated cellular uptake of neutravidin and delivers bound protein to lysosomes for degradation. Supplied as a white to off-white solid, it is highly pure and suitable for in vitro and in vivo formulation studies.
- Biotinylated ASGPR ligand for lysosomal targeting studies.
- Promotes receptor-mediated uptake of neutravidin into cells.
- High purity suitable for research applications.
- Soluble in DMSO (100 mg/mL) for in vitro use.
- Formulatable in recommended in vivo vehicles at ≥2.5 mg/mL.
- Stable as a powder at -20°C for long-term storage.
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 25 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group. It can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Azide group
- Undergoes CuAAc reaction
- Undergoes SPAAC reactions
Medchemexpress LLC Azido-PEG9-NHS ester | 2801772-87-0 | C25H44N4O13 | 25 MG
Azido-PEG9-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent with an azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Target PROTAC linkers
- Used in PROTAC pathway
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Apexbio Technology LLC Cy3 Bis NHS ester 25mg
Cy3 Bis NHS ester is a water-soluble fluorescent labeling reagent containing two amine-reactive NHS ester groups on a single dye molecule This compound specifically reacts with primary amines such as lysine residues on proteins or amine-modified nucleic acids enabling covalent fluorescent conjugation Upon formation of stable amide bonds with target molecules Cy3 fluorescence can be detected with standard fluorescence instruments exhibiting excitation at approximately 550 nm and emission near 570 nm Typical applications encompass labeling proteins peptides antibodies nucleic acids and other amine-containing biomolecules for fluorescence microscopy flow cytometry and biochemical assays as well as single-molecule fluorescence resonance energy transfer (FRET) studies